Reading this entire thread brought me to one conclusion: anyone trying to learn should go somewhere else.
As for the OP, heres my input: Shane and DanDan are about as spot on as you can get. You will need to control MANY of the vehicles prameters if you TRULY want to have a good tune. That is what will get you where you need to be. Haltech is the way to go because they have developed many ECU's for OEM's and race cars AND they know the complexity of tuning a motor. They keep this in mind when developing their products and thats how so many are able to achieve their output goals with the Haltech products. Timing is very important to control, and obviously fuel is too, but keep in mind that if you dont also tune the compensation maps for warmer or colder air and coolant temps, you WILL blow your motor. If you dont tune the Latency for your injectors or compensate for voltage drops when turning on your headlights and so on... they can all quickly add up to being a factor for blowing the motor. The Haltech will do all of that WITH A GOOD TUNE!!!
Like Shane said, having a knock light is a good idea. Having a J&S is a GREAT idea. Someone else mentioned the DocB oil system, Great idea. But for all of those that mentioned the standalone: BEST idea. I have blown my motor 3 times from a bad tune. I woud have to say, if you dont want to spend a lot of money, START there. Theres no way I have spent even close to $12000 for the 400hp I have. The only thing holding me back from 500+ is my transmission is going on 105k miles and I needed to get home from the dyno.
The best people to ask are the ones that have been there. DanDan mentioned having to do it over again after a mistake with the previous ECU set up. Theres nothing more frustrating than going cheap on something, just to have to pay for the repairs PLUS what you should have got in the first place. I decided to skip the connecting rods and dyno tuning on my second build. The $700 I saved cost me a couple grand when I had to buy a new block, pistons, bearings, oil pan and a bunch of other misc. stuff from the broken rod punching holes thru everything.