I haven't driven a car with cylinder deactivation. How long does it take to re-activate cylinders? If we are talking a few hundred milliseconds, then it may not affect acceleration enough to be noticeable. If it only comes into play when you are cruising at constant speed, and instantaneously reverts to 4 cylinders when you press the throttle, then it seems like all good assuming there aren't reliability problems.
If it decreases the maintenance interval for easy to replace spark plugs, that's a worthwhile trade-off. If it fouls sensors/controls and leads to ambiguous check engine codes, or premature engine failure - not good.
On the Hondas and Chevys, cylinder deactivation only kicks in at constant speed and light throttle. As soon as you press on the throttle it kicks out, and the transition feels pretty seamless to me. I've been told that if you listen carefully on a quiet road, you can hear a slight change in engine noise, but otherwise you probably won't notice it's working except by the dash indicator.
The main concern is oil fouling. You can change the plugs, but if there are deposits fouling the plugs, there are probably deposits in the combustion chamber as well. Honda also had problems with it wrecking engine mounts, but I think those have been solved.