I hear the new Odyssey minivan, which itself is a heavy pig, will get up to 28 mpg, and that's with their 3.5L engine. So obviously there is a way to squeeze more mpg, not sure how Honda is doing it.
Edmunds:
The EX-L and Touring models come equipped with Variable Cylinder Management (VCM), which deactivates up to three cylinders when coasting. This system allows those particular Odysseys to return an EPA-estimated 17 mpg city/25 mpg highway and 20 mpg combined -- a notable improvement over the base engine's 16/23/18. In performance testing, we accelerated a Touring model from zero to 60 mph in 9.1 seconds -- slower than some competitors, but still respectable.