No matter really if you listen to it that loud, you can always turn it down and it'll sound thatmuch better. I had an EA5422 before my tsunami (didn't really upgrade I know, but I've got matching amps now, and it was part of how I afforded it) Anyway, AWESOME amp, if you can swing it, get it! It's always much easier as far as space, and wiring, ans, well most anything is concerned to run 2 amps than 3 anyway, and like I said, with a 4212, you'd need another form of high-pass crossover seeing as it's only got a built in lowpass. the 5422's got both built in. Heck, if you wanted you could run it in 3-channel mode, and run your front speakers off of 2 then bridge the rears to your sub.
As far as power, I really wouldn't worry about it. I'm running a 4x75 and a 1x1100. I've got a voltage meter in my dash, and I only see a healthy drop whenI listen to rolling low baseline music rediculously loud. Still, though my voltage stays above 13.5 (my resting battery voltage) without a problem. I know there's more than what voltage it reads, and I'm looking into getting a capaciter of some sort, but everything's peachy for now. I'd make sure, though to get a "class d" or T sub-amp. They're much more power efficient (draw about half as much power as a comparable A or a/b class amp for the same output) You pay for it in SQ, but with a sub it's not as vital.
Speaking of subs... CHeck elemental designs out. AWESOME stuff. They've got a pretty good deal on their 8a's going right now I believe, too. I've got a 12, and I can't really speak for anything else they make, but this thing can freaking POUND! out-hits anything similar I've heared, and it's higher-range blends very nicely with my mids up front.