Simply put: Archer and the crew of enterprise have gone into the expanse to seek out the Xindii - a race made up of (i believe) 5-6 different type of species - who are creating a biological weapon to destroy the human race. Seems the Xindii were foretold that humans would destroy their planet in the near future.
Smallville - a show that rocks! and is essentially a prequal to Supes, The Legend. Jonathon? sacrifice to return Clark? A bad heart, since we know he eventually dies of complications due to an MI. The Book of Mormon...uhhhh IMHO....no. Good call on the reference to DC universe, though.
I'm a fan of BOTH shows - both offer great writing, fun stories - if predictable. Did anyone notice how the story lines of "Buffy" went down the toilet after it switched networks?