No doubt lowering your car will change the handling, ride and wear characteristics of your vehicle. Lowering reduces the amount of travel in you suspension and stiffens the ride signifigantly. The lower you go the stiffer the spring and shock you use. You are trying to keep the car from bottoming out which is undesireable as it actually negatively effects your handling at that point. Additionally, lowering changes the alignment of your car, more negative camber for instance, which could be desirable as that will help you turn better, but could also cause the inside shoulders of your tires to wear prematurely. It is best if you can get a camber kit installed when you lower the vehicle to make sure that you can still adjust the alignment to proper specs. When you lower you also lower the center of gravity which is a good thing. It really all matters what you goal is for lowering. Is it for looks or performance? You may be able to accomplish what you want without changing the suspension at all. Just changing the alignment specs or tires or tire pressures. If you just want to slam it for looks, you should still make sure your alignment can be adjusted enough to make sure you don't create too much wear on you tires.