I switched from NGK's to +4's on my CRX, and the fuel economy went for a s**t.
Switched back to NGK's after a few months, and everything was good again.
I had them on my protege5 before i went nitrous..and i think that it gave the car better throttle response....but inreference to the gas...i don't know..i only had them on for 1 month!
I've got a set of the +4's in now, have been in for about 6 months. No problems, gas mileage is the same...maybe a little better throttle response but minimal.