Warranty period is about the same. Price about the same. I drove both and know they drive differently. The interior of the RX is pretty darn great.
I'm not a snowflake, I am 55 and insults (subtle please) are ok. LOL! RX 350 = Chick car??? I drive a Tacoma now
I used to be all about "buy the car that fits your image". Then my horizons expanded a bit. I went to do some training, and one of the guys hosting it, SF, 75th Rangers, rolled up in a VW Jetta. Massive dude unfurls from the driver's seat, and that's that. I wrote it up as a 1-off. Then a Delta guy rolls up...in a Honda Pilot. We are all talking cars at some point, and he finds out I'm looking at an SUV. He promptly suggests a Honda Element, since I won't be towing and don't have a family.
At this point I realize people that my government has spent literally millions of dollars per, on, to train to invade enemy countries and raise an insurgency, or charge across poppy fields in Iraq with NODS and suppressed weapons and mow down the enemies of freedom...really don't care what they drive.
I had to take stock in how I viewed vehicles and ask myself...am I my vehicle? The obvious answer was "I am not".
This does not mean I do not have preferences in vehicles and styling, but the mission should drive the gear...not the lipstick on the hog.
So now, that out of the way...
I personally feel the Lexus will last longer. It will go further. It will be more reliable. The V6 in that thing is an absolute work of perfection, if "lasts forever" is your target goal. The transmission in it is also EXCELLENT.
Now functionally: Is the Lexus AWD, as well? Do you enjoy the CX5 or the Lexus more, as the CX5 IS more athletic, in the 2 trims you are comparing the respective vehicles in.
If I enjoyed both vehicles equally, and found they both equally met my needs, I would buy the Lexus without hesitation due to what I feel is a very high likelihood of it lasting longer, and that means I can get to retirement quicker, however, you being 55...may have different priorities, as you may well have a lot more money than I, and/or already be retired, and this purchase is not necessarily as utilitarian as my purchase would be. So the less reliable, but more fun vehicle, MIGHT be something you are into.
At 55? If you can't afford either one, you've done it all wrong, and might as well just continue and have fun, lol! And at 55, if you CAN afford either one, both will be inconsequential to you compared to the other, maintenance/longevity-wise.
So...buy the one t hat makes you smile more!