No, you have it backwards. The Mazda manual requires NO MORE than 10% ethanol. Our cars are not designed for e85. e85 requires injectors that are capable of pushing more fuel as e85 does not have the same amount of energy as regular gasoline and more of it is required during combustion. Cars can run e85 have injectors that support this, fuel lines that support this, and the engine control systems are designed to increase fuel rates to accomplish this.
Cars can generally run more timing and boosted cars can run more boost pressure when running e85 because it has an effective octane rating that is closer to race fuels than street fuels. HOWEVER, more fuel is used and you will get worse mileage running e85 in ANYTHING, whether is is designed for it or not.
I would not recommend running e85 in a Mazda5 AT ALL. I know people that run e85 in cars that aren't certified for it, but they have tuned the cars and modified them so they can run it. They sit there with laptops watching data to make sure it's ok. It's not something you just put into a normal car.