I think the difference is measurable in the real world but only if proper controls are in place.
The increase in mpg (with moly) isn't immediate because it takes some running in to get the engine components "burnished" with moly. And when you switch back to low/non-moly oil, the decrease isn't immediate either because engine components will still be burnished with moly from previous fills. Also, on the first use of moly, much of the moly is consumed in the burnishing process so the best results won't be until the second change with moly.