You should not use anti-seize on NGK spark plugs because they feature a special trivalent plating on the threads, acting as a built-in lubricant and corrosion inhibitor, making anti-seize unnecessary and potentially harmful by causing over-tightening, leading to thread damage, shell stretch, or breakage. NGK plugs are designed to be installed dry to ensure correct torque and heat transfer, preventing serious engine issues like pre-ignition from altered heat ranges or stripped cylinder head threads.