Hillsborough River State Park is located 9 miles north of Tampa and 6 miles south of Zephyrhills on US Highway 301.
From I-75, Southbound from Ocala take the SR 54. Exit #279 east to Hwy 301, travel South for 6 miles, and the park will be on your right-hand side.
From I-75, Northbound from Tampa take the Fowler Ave. Exit #265 east to Hwy 301, travel North for 9 miles, and the park will be on your left-hand side.
From I-4, West bound take Exit 10 go north on CR 579 to US 301, follow the signs and go North 7 miles the park will be on your left-hand side.
From I-4, East bound take Exit 7 (be careful of the merges) and go North on US 301 for 14 miles, the park will be on your left-hand side.