IMHO, the best two tires are the H/L 422 Ecopia and the Michelin Latitude tour HPs. The Spec-X are a great tire for traction and noise, but have poor wear (documented). The thing that turned me off was the lower wet and dry traction of the 422's. Don't just pay attention to the specs tab on Tire Rack, as those are user data input, but look at the test tab. The Spec-X has never been tested for Tire Rack even though it has been a very popular tire among CX-9 Users (odd). The Latitudes have a special compound that lowers static friction supposedly, therefore increasing MPG; the jury is still out on that one for me. If you are going to spend $920 on 422s, IMO go the extra $70 and get the Latitudes. I am really impressed by them.
I previously had the Pirelli Scorpion STR-As. They were a good tire that I changed out at 47K, but they had a bit more tread life on them. The roads here have a lot of crushed marble in them, so when it rains they get slick. I slid often with the Pirellis, but I have had the chance to try the Latitudes on the wet roads here and I can say that they are far superior. The tread blocking system on the tires hold up on cornering because trust me, the average speed on the autostrada is 80 mph and the smaller roads are windy too.