The guys on Mythbusters tried it and actually lost a little mpg... not enough to be statistically significant.
I think their car got 18mpg on gas, 16 on the mixture...
Anyways, acetone is a solvent, and I just don't think it's a good idea to pour that in my car, but you're free to do it if you feel like it.
Acetone is the primary ingredient in nail-polish remover. And while it will burn and is a high-octane material, it’s also a very powerful solvent. So while it’s in your fuel system, it’ll be eagerly dissolving all of your rubber components ... like gaskets and O-rings. And if you spill any on your paint while pouring it in the gas tank, it will eat through paint like it's a cheeseburger. There are also a couple of rumors also that acetone will kill your injectors.
Here's an article I found from ABC Channel with some engineers actually testing it out:
http://abclocal.go.com/wjrt/story?section=resources/auto&id=3951510
You can also look for the mythbusters episode on their website or youtube, I'm too lazy to look it up.
-->Aside from having no effect on mileage, acetone could actually do harm by damaging hoses and fittings. Carmakers don't like acetone either.
-->"If they know you did it, they could void the warranty," Davis warned.