I have been doing this same thing - ever since my Scanguage hooked up to my old car, I've tried to measure MPG (the old fashioned way) and compared to the Scanguage with the variance it allows you to correct each fillup.
Same thing with the Mazda. My route and traffic are pretty much consistent week to week. Unlike what many say here, my computer will recalculate on as little as adding 2 gallons of gas!
In the 4 months since I've gotten it, I've disconnected the battery twice (for mods) and watched the calculations change, slowly but surely. It started like 4-5mpg off, whittled down, and now, after about 6 weeks, I can safely say it's only 1-2 mpg off at most. I use only a select few gas stations depending on if I'm staying here in Newport News or driving to Maryland (which I do monthly), and while it may not be absolutely accurate down to the mile, when the computer tells me I have 50 miles left, it's pretty close when I add it all up at the next fillup and calculate manually.
It worked well enough for me to determine that my car gets better mileage with the AC on and windows up at highway speeds halfway through the trip (I know, they all say it should, but this is the first car where I did see that. My 3 Nissan prior to this preferred windows down). It made a difference of 4mpg windows up versus halfway down.
I will probably steal the scanguage from my girl (she drives the Sentra now) and, using it's variance adjustment, try for a month and just see how accurate it can be