Sahara is a bit out of the way (although it is on the strip).. i'd suggest looking into Harrahs or Flamingo since they are located pretty much in the middle of the strip AND they have a monorail stop at each of those, so you can leave your room and walk to the monorail to get to distant ends of the strip if you don't feel like walking.. (or if you do feel like walking, you can catch the monorail back to your room so you don't have to walk the round trip!)
they are both harrahs properties, so check out
www.harrahs.com for more info.
Also, Flamingo has a real nice pool area and when I was there last July, they did pool parties on Saturday with plenty to look at if you know what I mean
Some other fav's of mine are Caesar's, Treasure Island and Rio. Rio is off the strip, but has a shuttle that runs to several stops on the strip pretty regularly (every 20 mins).
Big money locations: Bellagio, Venetian, Mandalay Bay, but for the amount of time you'll spend in the room, I don't find it worth it.
I'll probably miss you by about a month (going back in Late May) and then again in November for my usual anniversary trip. Also, I was just there in January for CES (and of course this past November for my anniversary). I just wish it wasn't a 5 hour flight to & from Baltimore!!
Have fun!
edit: here's a nice 3D map courtesy of the Las Vegas Monorail. You can see Sahara is as far north on the (new) strip as it gets:
http://www.lvmonorail.com/ride/route_map/ (the strip is about 4 miles long, i know the map can be deceiving and make it look like a shorter walk, but Sahara (far north) versus Mandalay bay (far south) are both on the strip but also in seperate zip codes (89109 versus 89119)!!